Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling
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چکیده
Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.
منابع مشابه
The modic vertebral endplate and marrow changes: pathologic significance and relation to low back pain and segmental instability of the lumbar spine.
Two decades following their description, the significance of Modic vertebral endplate and marrow changes remains a matter of debate. These changes are closely related to the normal degenerative process affecting the lumbar spine, and their prevalence increases with age. However, the exact pathogenesis underlying these changes and their relation to segmental instability of the lumbar spine and t...
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STUDY DESIGN Prospective cohort study. PURPOSE In this study, we investigated the frequency of vertebral endplate Modic changes (MCs) and their effects on surgical outcomes in patients with unstable lumbar spines. OVERVIEW OF LITERATURE Signal changes in endplates have been classified into three types by Modic. The prognostic role of MCs has been investigated in various spinal disorders. ...
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